Download White Papers

Research Study Information

Methylene blue improves brain oxidative metabolism and memory retention in rats

Callaway NL, Riha PD, Bruchey AK, Munshi Z, Gonzalez-Lima F.
Pharmacol Biochem Behav. 2004 Jan;77(1):175-81. doi: 10.1016/j.pbb.2003.10.007.

The brain metabolic enhancer methylene blue improves discrimination learning in rats.

Wrubel KM, Riha PD, Maldonado MA, McCollum D, Gonzalez-Lima F.
Pharmacol Biochem Behav. 2007 Apr;86(4):712-7. doi: 10.1016/j.pbb.2007.02.018. Epub 2007 Mar 6.

Methylene blue restores spatial memory retention impaired by an inhibitor of cytochrome oxidase in rats.

Callaway NL, Riha PD, Wrubel KM, McCollum D, Gonzalez-Lima F.
Neurosci Lett. 2002 Oct 31;332(2):83-6. doi: 10.1016/s0304-3940(02)00827-3.

Memory facilitation by methylene blue: dose-dependent effect on behavior and brain oxygen consumption.

Riha PD, Bruchey AK, Echevarria DJ, Gonzalez-Lima F.
Eur J Pharmacol. 2005 Mar 28;511(2-3):151-8. doi: 10.1016/j.ejphar.2005.02.001.

Extinction memory improvement by the metabolic enhancer methylene blue.

Gonzalez-Lima F, Bruchey AK.
Learn Mem. 2004 Sep-Oct;11(5):633-40. doi: 10.1101/lm.82404.

Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways.

Atamna H, Nguyen A, Schultz C, Boyle K, Newberry J, Kato H, Ames BN.
FASEB J. 2008 Mar;22(3):703-12. doi: 10.1096/fj.07-9610com. Epub 2007 Oct 10.

Neuroprotective and Functional Improvement Effects of Methylene Blue in Global Cerebral Ischemia.

Lu Q, Tucker D, Dong Y, Zhao N, Zhang Q.
Mol Neurobiol. 2016 Oct;53(8):5344-55. doi: 10.1007/s12035-015-9455-0. Epub 2015 Oct 3.

Therapeutic and preventive effects of methylene blue on Alzheimer’s disease pathology in a transgenic mouse model.

Paban V, Manrique C, Filali M, Maunoir-Regimbal S, Fauvelle F, Alescio-Lautier B.
Neuropharmacology. 2014 Jan;76 Pt A:68-79. doi: 10.1016/j.neuropharm.2013.06.033. Epub 2013