NAD – 200 mg/day

Essential cofactor for cellular energy production via NADH → electron transport chain.​

Fuels all seven sirtuin enzymes (SIRT1–7) for DNA repair, genomic stability, and mitochondrial biogenesis.*​

Works synergistically with pterostilbene to increase whole‑blood NAD+ levels by 40–90% in clinical trials.​

Provides electrons to CoQ10 in Complex I of the mitochondrial respiratory chain.*​

Pterostilbene – 100 mg/day

Potent SIRT1 activator with 80% bioavailability (4× higher than resveratrol).

Clinically proven synergy with NAD precursors: NR + pterostilbene combination safely raised NAD+ by 90% and improved diastolic blood pressure, liver enzymes (ALT), and cholesterol metabolism in elderly adults.

Supports healthy glucose metabolism, cognitive function, and cardiovascular health.*

Superior membrane permeability and longer half life than resveratrol ensures sustained sirtuin activation.*

CoQ10 (Ubiquinone) – 200 mg/day

Central electron carrier in mitochondrial Complexes I, II, and III, accepting electrons from NADH and FADH₂ to drive ATP synthesis.*

Maintains CoQH₂/CoQ ratio, a key sensor of metabolic status and mitochondrial efficiency.*

Dual antioxidant role: reduces ROS at the mitochondrial membrane and regenerates vitamin E and vitamin C.*

Combined CoQ10 + NAD creates synergistic enhancement of mitochondrial function beyond single supplementation.*

Naturally depletes with age and statin use; supplementation at 200 mg/day restores optimal tissue levels.*

Fisetin – 40 mg/day

Emerging senolytic flavonoid that supports the body’s natural clearance of senescent (“zombie”) cells.*

Works synergistically with other flavonoids and NAD+ boosting compounds for enhanced cellular health benefits.*

Supports brain health, neuroprotection, and healthy inflammatory pathways.*

Daily low dose fisetin (40 mg) provides gentle ongoing senotherapeutic support, distinct from high dose intermittent senolytic protocols.*